Genetic variants in RAB3GAP1 have been shown to cause a polyneuropathy comparable to Warburg syndrome in the Alaskan Husky, Rottweiler, and Black Russian terrier breed, with manifestations including microphthalmia (Wiedmer et al. 2015; Mhlanga-Mutangadura, Johnson, Ashwini et al. 2016; Mhlanga-Mutangadura, Johnson, Schnabel et al. 2016). The gene discussed is RAB3GAP1; the disease is microphthalmia.