In this study, we searched potential ferroptosis regulatory genes by analysing datasets from the public databases Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA), and six differentially expressed genes (DEGs) were screened to be potentially involved in the regulation of pancreatic cancer cell ferroptosis, among which HSPB1 is an exosomal protein and relatively less characterized regulator in pancreatic cancer. Here, HSPB1 is linked to pancreatic neoplasm.