It was reported that human pancreatic cancer cells SW1990 derived exosomes promoted the proliferation, migration and cell cycle progression of HPDE cells, while exosomes with downregulated expression of hsa_circ_0000069 inhibited HPDE cell proliferation, migration and cell cycle progression by inhibiting STIL expression and inhibited pancreatic cancer progression.26 Here, STIL is linked to familial pancreatic carcinoma.