The online bioinformatic tool Jvenn was then used to intersect DEGs among the GSE157830 dataset and TCGA‐PAAD project, and the results showed that there were six intersecting genes that both downregulated in response to Dox treatment in GOT1 knocked‐down Tu8902 and MiaPaCa cells and simultaneously upregulated in PAAD tissues, including HSPB1, MMP9, PIK3R3, MET, FGFR1 and CDK6 (Figure 2C). Here, HSPB1 is linked to pancreatic adenocarcinoma.