In this study, we reported that Nrf2/HO‐1 was activated by cancer cell‐derived exosomal HSPB1 in hypoxic pancreatic cancer cells via FUS protein, and knockdown of HSPB1 or FUS caused suppression of Nrf2/HO‐1, increased the level of the ferroptosis fuel P450 oxidases,48, 49 and inhibited pancreatic cancer progression in vitro and in vivo. The gene discussed is HMOX1; the disease is familial pancreatic carcinoma.