Using unifactorial and multifactorial joint construction of ROC curves for analysis, ALB (AUC = 0.896), HDL-C (AUC = 0.728), hypertension (AUC = 0.660), diabetes mellitus (AUC = 0.588), and alcohol consumption (AUC = 0.603) had diagnostic potential for IS. The gene discussed is ALB; the disease is Hypertension.