Autoimmune optic neuritis includes distinct subtypes such as neuromyelitis optica-related optic neuritis (NMO-ON), collapsin response mediator protein 5 optic neuritis (CRMP5-ON), myelin oligodendrocyte glycoprotein ON (MOG-ON), multiple sclerosis ON (MS-ON), single isolated optic neuritis (SION), relapsing isolated optic neuritis (RION), and chronic relapsing inflammatory optic neuropathy (CRION). The gene discussed is DPYSL5; the disease is optic neuritis.