Studies have previously associated POAG with genetic variants at the intergenomic region of TMCO1 and ALDH9A1. 47, 48, 49 The results of this study point toward ALDH9A1 being the implicated gene in POAG due to inducing a greater degree of morphological change compared with TMCO1 (P = 7.78 × 10−05). The gene discussed is TMCO1; the disease is open-angle glaucoma.