LTBP2 and open-angle glaucoma: Variations in LTBP2 have been previously associated with primary congenital glaucoma, microspherophakia, megalocornea, and Weill-Marchesani syndrome.26, 27, 28, 29 A previous study has identified that LTBP2 knockout may contribute to the development of POAG via dysregulation of the extracellular matrix, a crucial component of the trabecular meshwork.30