,6 Linkage analysis identified variants in the MYOC gene as being strongly associated with POAG.7, 8, 9 Disease-causing mutations in this gene have been shown to cause accumulation of a misfolded protein (myocilin), resulting in endoplasmic reticulum stress in trabecular meshwork cells (TMCs) and a subsequent rise in IOP.6 This evidence concerns the gene MYOC and open-angle glaucoma.