MYOC, CYP1B1, GMDS, and FOXC1 knockouts resulted in only mild differentiation from control TMC morphology (AUCs of 0.615, 0.612, 0.704, and 0.665, respectively) despite an association with glaucoma and anterior segment dysgenesis;7,37, 38, 39, 40 however, these genes were seen to have low knockout efficiency which may explain the limited morphological change. Here, CYP1B1 is linked to glaucoma.