Variations in TEK have been associated with raised IOP and congenital glaucoma primarily due to disruption of Schlemm’s canal, indicating a potential interaction with ANGPT1 in the development of glaucoma.33, 34, 35, 36 However, it must be noted that the knockdown efficacy of TEK in this study was insignificant (P = 0.858), indicating that the learned morphological variation may be due to a confounding factor learned by the deep learning system. This evidence concerns the gene TEK and glaucoma.