CAV2 and open-angle glaucoma: There have also been numerous studies illustrating an association between POAG and variations at the intergenomic region of CAV1 and CAV2. 51, 52, 53, 54 This analysis prioritized CAV2 as a potential causative gene, with a higher degree of morphological change from control cells than CAV1 (P = 4.00 ×10−03).