Additionally, the relationship between IGF2BP2 and autophagy was further substantiated through a mIHC assay performed on a TMA containing tumor samples, which revealed a significant positive correlation between IGF2BP2 and p62 expression (Figure 4), suggesting that IGF2BP2 is clinically relevant in modulating autophagy during glioma progression. Here, IGF2BP2 is linked to central nervous system cancer.