Additionally, the relationship between IGF2BP2 and autophagy was further substantiated through a mIHC assay performed on a TMA containing tumor samples, which revealed a significant positive correlation between IGF2BP2 and p62 expression (Figure 4), suggesting that IGF2BP2 is clinically relevant in modulating autophagy during glioma progression. The gene discussed is SQSTM1; the disease is glioma.