ACAN and ocular melanoma: Intriguingly, the most significantly overrepresented ontology term in the DP OM (Figure 4b) was “skeletal system development,” which has daughter terms including “bone cell development,” “ossification involved in bone maturation,” and “mesenchymal cell differentiation involved in bone development.” Genes, including COL5A2, COL1A1, ALPL, HAPLN3, TGFβ2, and ACAN, were upregulated in DP OM versus PFi OM and were associated with the “skeletal system development” ontology term (Figure 4a).