RTEL1 is linked to pulmonary fibrosis (Jenkins, 2020), TRIM34 plays a role in restricting HIV-1 infection, PPP2R2A is a potential therapeutic target, and IRF7 shows high expression in certain COVID-19 patients, underlining the diverse implications of these genes in the context of SARS-CoV-2 infection. The gene discussed is IRF7; the disease is COVID-19.