NFKB1 and hepatitis C virus infection: KEGG enrichment for metabolic alterations in patients with SARS-CoV-2 infection also revealed differences between lung and PBMC samples: lung samples showed downregulated genes affecting lysosome and ribosome pathways, while upregulated genes were tied to pathways like hepatitis C and NF-κB, with an observed increase in NF-κB activation in lung infections.