This correlation may be related to the fact that visceral adipose deposition, which poorly correlates with BMI [21–23], leads to defective and swollen adipocytes secreting greater amounts of inflammatory cytokines such as interleukin-6 and tumor necrosis factor-α and excessive fatty acids but less of the protective fat-derived hormones like adiponectin that play a crucial role in protecting against insulin resistance and obesity [24, 25]. This evidence concerns the gene TNF and obesity due to melanocortin 4 receptor deficiency.