Indeed, severe insulin resistance and ectopic lipid accumulation are the major characteristics of patients with both lipodystrophy (2) and various murine models of lipodystrophy such as transgenic mice overexpressing sterol regulatory element-binding protein-1c in adipose tissue under the aP2-promotor (3), fat-specific nuclear receptor peroxisome proliferator-activated receptor gamma (PPARγ) knockout (KO) mice (4), and adipocyte-specific tamoxifen-inducible insulin and insulin-like growth factor-1 (IGF-1) receptor KO mice (5). Here, INS is linked to Insulin resistance.