VDR and vitamin D deficiency: Accumulative evidence has shown that vitamin D deficiency significantly attenuated the affinity of VDR to vitamin D, influenced the development, maintenance, and survival of neurons, and impaired other treatment of traumatic brain injury, resulting in neurodegeneration, neuronal aging and damage, which predicts a high risk of neurodegenerative diseases (Valdivielso and Fernandez, 2006; Vinh Quôc Luong and Thi Hoàng Nguyên, 2012).