KEGG pathway enrichment analysis revealed that the core targets of ZQCLD were enriched in 50 pathways, including fluid shear stress and atherosclerosis, TNF signalling pathway, IL-17 signalling pathway, advanced glycation end product (AGE)-receptor for AGEs (RAGE) signalling pathway in diabetic complications, and malaria (Supplementary information 3, Table S5). This evidence concerns the gene TNF and atherosclerosis.