PDPN and Fabry disease: Similarly, there are mechanisms other than PDPN that activate fibroblast contractility which likely play important roles in the fibrotic activation of fibroblasts.132–135 Thus, the combination of contraction-induced durotaxis and selective sparing of myeloid and granulocyte chemokine expression already appears to differentiate fibroblast functions in FD from those in IMID.