Unlike the macrophages and neutrophils that predominate in fibrosis-associated leukocyte infiltrates, DCs express the PDPN ligand CLEC-2, which decouples PDPN from ezrin and inhibits fibroblast contraction.108,109,136 This is one way that early differences in the composition of leukocyte infiltrates may result in different fibroblast functions and clinical pathologies in IMID and FD. The gene discussed is PDPN; the disease is Fabry disease.