LTBR and Fabry disease: Antagonizing LTβR signaling was sufficient to reduce or inhibit CXCL13 production in the non-obese diabetic (NOD) model of SS and a model of autoimmune pancreatitis.192,194,197 IL-22 production is necessary for induction of CXC13 by salivary gland and lung fibroblasts, but the salivary gland induction depends on LTβR while the lung does not.154,214 Together, these data suggest that a stepwise dialogue between leukocyte infiltrates and fibroblasts causes fibroblast differentiation that may separate IMID from FD.