SIRIUS (Safety and efficacy of an Intravenous placebo-controlled Randomized Infusion of Ularitide in a prospective double-blind Study in patients with symptomatic, decompensated chronic heart failure): Effects of the renal natriuretic peptide urodilatin (ularitide) in patients with decompensated chronic heart failure [19,20]. The gene discussed is NPPA; the disease is congestive heart failure.