On the other hand, RRAS2, a small GTP-binding protein that is a member of the RAS superfamily, has been reported to be important in malignant transformation by playing an important role in regulating RAS signaling [64]. Moreover, RRAS2 was also reported to be upregulated in osteosarcoma, and its high expression is associated with poor prognosis. The gene discussed is RRAS2; the disease is osteosarcoma.