HRAS and bone neoplasm: STAT-3 activated in bone tumors such as Ewing's sarcoma has been reported to be a result of continuous activation of EGFR signaling [37, 38]. In a study conducted by Oda et al., it was reported that H-RAS mutation was present in a small number of synovial sarcoma cases, and this mutation was not associated with the clinicopathological characteristics of the patients [39].