Investigators have found that differential expression of the TFs ASCL1, NEUROD1, POU2F3, and YAP1 defined four molecular subtypes of SCLC, respectively, and that these TFs co-localized with SEs in the corresponding SCLC subtypes (Borromeo et al., 2016; Huang YH. The gene discussed is ASCL1; the disease is small cell lung carcinoma.