In animal models, subcutaneous injection, intraperitoneal injection and dietary nicotine can stimulate nAChR receptors, mainly the α7-subunit, but also the α3-, α5-, β2-and β4-subunits, inhibit proinflammatory cytokines such as IL-6, TNF-α, IL-1β, IL17 and IFN-γ produced by immune cells through the AMPK/mTOR/NF-κB/Stat3 inflammatory signaling pathway and AMPK-mTOR-P70S6K autophagy pathway, to alleviate ulcerative colitis induced by different inducers such as dextran sodium sulfate (Snoek et al., 2010; Lakhan and Kirchgessner, 2011; Gao et al., 2020). Here, MTOR is linked to ulcerative colitis.