SERPINE1 and Sepsis: Nicotine could inhibit the activation of the NF-κB anti-inflammatory pathway through stimulating α7 nAChR and suppressing the secretion of high mobility group protein B (HMGB1), thereby inhibiting the production of proinflammatory cytokine plasminogen activator inhibitor-1 (PAI-1) as well as the microcirculation damage caused by sepsis.