Carlino et al. showed that any combination of the presence of bilateral ischemia (IS) (defined as ≥3 BLC), pleural effusion (PE) (defined as hypoechoic space between the two pleural walls), or a dilated left atria outperformed traditional diagnostic tools such as pro-BNP or chest x-ray in sensitivity, specificity, and accuracy 10. Here, NPPB is linked to Pleural effusion.