LGALS3 and heart disorder: As we all know, gal-3 had been previously proved to be a prognostic biomarker of various heart diseases, such as acute or chronic heart failure (de Boer et al., 2011; Lok et al., 2013; van Vark et al., 2017), valvular heart disease (Kortekaas et al., 2013), even in patients with heart failure (Gopal et al., 2012), the level of gal-3 is negatively correlated with renal function.