But by inducing Peroxisome proliferator activated receptor-α(PPAR-α)-BNIP3 pathway to maintain mitochondrial steady-state signal, restrain mtROS and inflammatory reaction (Pawlak, Lefebvre & Staels, 2015), reduce the expression of fibrosis markers, so as to relieve the progress of CKD. Here, BNIP3 is linked to chronic kidney disease.