Recent study has shown that Nrf2 activation can promote PINK1/Parkin mediated mitophagy in obesity-related CKD, effectively reduce oxidative stress level and inhibit mitochondrial depolarization in renal tubular cells, thereby protecting mitochondrial function and reducing kidney damage induced by high fat diet (HFD) (Ding et al., 2022). This evidence concerns the gene PRKN and obesity due to melanocortin 4 receptor deficiency.