Notably, we identified EOCRC tumor-specific splicing of ZBTB7B (Th-POK), a zinc finger transcription factor which controls T-cell differentiation into CD4+ or CD8+ T-cells (74), and MAP3K8 (TPL2), a driver of oncogenic inflammation (75), though the biological function of these splice variants remains unknown. This evidence concerns the gene CD8A and neoplasm.