The outcomes revealed that LY (P = 0.027), tumor burden (P = 0.033), N classification (P = 0.006), radiographic response (P < 0.001), pulmonary atelectasis (P = 0.022), and pre-treatment PD-L1 expression levels (P = 0.013) were independent elements influencing MPR achievement following NCIO in patients with potentially resectable LUSC (Table 3). Here, CD274 is linked to neoplasm.