HMOX1 and liver disorder: The Nrf2 is stimulated using nitrogen-based and oxygen-derived radicals resulting from metabolic sources [16] and activates the expression of the multidrug resistance-associated proteins (MRPs), NAD(P)H quinone oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1) genes which act against liver diseases in several ways [14].