Also, treatment with a mitochondrially targeted antioxidant, MitoTEMPO, reduced sudden cardiac death in ACE8/8 mice; decreased spontaneous ventricular premature beats, ventricular tachycardia inducibility, and mitochondrial ROS; prevented structural damage to mitochondria; resulted in an increase in Cx43 at the GJs; and corrected GJ conduction [35]. This evidence concerns the gene GJA1 and ventricular tachycardia.