The findings of our study are important for individuals with genetic defects in TNFAIP3 (or functionally related genes), which are associated with increased susceptibility to various inflammatory and autoimmune pathologies, such as rheumatoid arthritis, systemic lupus erythematosus, multiple sclerosis, and psoriasis (43). This evidence concerns the gene TNFAIP3 and systemic lupus erythematosus.