Additionally, in Sle3/5 R4A-γ2b C57BL/6 mice that express both the H chain transgene and the Sle3/5 lupus susceptibility range, PRL decreases the T1:T2 B ratio and promotes autoreactive B-cell accumulation in splenic follicles. The gene discussed is PRL; the disease is systemic lupus erythematosus.