TLR4 and myocardial ischemia: Moreover, Huang et al. investigated the role of circ_SMG6 in myocardial ischemia/reperfusion and found that it can worsen myocardial I/R injury; in addition, they found that neutrophil recruitment is promoted through the miR-138-5p/EGR1/TLR4/TRIF signaling pathway, which provides a new direction for research on the treatment of myocardial I/R injury [65].