TOP2A and bacterial infectious disease: Among the various antibacterial targets,bacterial type II topoisomerases,such as DNA gyrase and its paralogous equivalent topoisomerase IV(topoIV), proved to be well validated in treating bacterial infections.The main function of DNA gyrase enzyme is to maintain a correct spatialtopology of the DNA molecule through introduction of negative supercoils,while topoIV is responsible for DNA decatenation activity during therecombination and replication processes.