CLU and Alzheimer disease: In GWASs, a significant association with AD was alsoshown for the CLU (APOJ, encodes apolipoprotein J), CR1(encodes complement component 3b/4b) (Lambert et al.,2009), APOE (encodes apolipoprotein E), PICALM (encodesprotein phosphatidlinositol-binding clathrin assembly) (Haroldet al., 2009; Ando et al., 2022), BIN1 (Ando et al., 2022)genes.