BIN1 and Alzheimer disease: In 2021, a meta-analysis showed an associationof 23 different SNPs with AD, among which the highestsignificance was determined for rs3865444 (in the CD33transmembrane receptor gene), rs7561528 (in the nucleocytoplasmicadapter protein gene (BIN1)) and rs1801133 (in themethylenetetrahydrofolate reductase gene (MTHFR)) (GNSet al., 2021).