SMAD3 and Ureteral obstruction: Thus,honokiol – a SIRT3 activator – counteracts kidney fibrosis inmice with unilateral ureteral obstruction (Quan et al., 2020).Similarly, activation of both SIRT1 and SIRT3 by resveratrolattenuates cardiac fibrosis in mice by inhibiting the TGF-β/Smad3 pathway (Liu et al., 2019).