Itsnuclear export depends on posttranslational modificationsand can be disrupted by various stimuli (North, Verdin, 2007).For example, infection of HeLa cells with Listeria monocytogenesbacterium leads to dephosphorylation of SIRT2 by S25residue, which leads to an increase in the nuclear concentrationof the protein. The gene discussed is SIRT2; the disease is infection.