For example, the activation of SIRT1 hasbeen found to increase proliferation, invasion, and accelerateepithelial-mesenchymal transition in pancreatic tumor cells,which is associated at least in part with suppression of geneexpression of the FOXO3 and GRHL3 transcription factors(Leng et al., 2021). The gene discussed is SIRT1; the disease is pancreatic neoplasm.