Similarly, a 9–16 % increase in mouselifespan was achieved by triggering transgenic SIRT1 specificallyin hypothalamic cells (Satoh et al., 2013), whereas inan earlier study, an overexpression of SIRT1 in mice did notaffect longevity, although it reduced the likelihood of cancer(Herranz et al., 2010). This evidence concerns the gene SIRT1 and cancer.