TRPM8 and central nervous system cancer: Similar to the BK channels, Kir4.1 is a K+ channel with altered expression in the glioma.165 Its expression was negatively related to glioma migration and invasion behavior.166 In a word, TRPM8 is closely related to glioma signaling pathways, including the MAPK signaling pathway and CaMKII, BK, and Kir4.1-K+ channels.