Previously, many studies have confirmed that the cytotoxic effect of curcumin on glioma cells is closely related to the induction of cell apoptosis and autophagy.168 The combination of curcumin and cisplatin suggested that curcumin enhanced cisplatin-induced death of human laryngeal squamous cell carcinoma (LSCC) cells through TRPM2.169 Cisplatin is a taxane widely used in glioma, breast cancer, and prostate cancer chemotherapy. This evidence concerns the gene TRPM2 and central nervous system cancer.