TRPM8 and cancer: Furthermore, one study found two TRPM8 variants, with a more significant menthol-induced increase in Ca2+ influx observed in migrating cells than in non-migrating cells, possibly indicating that only migrating cells express full-length TRPM8 proteins in the plasma membrane.63 Nevertheless, these results must be treated with caution in future cancer treatment strategies, as TRPM8 has been found to have anti-migration activity against other cancers, such as prostate cancer.145 Interestingly, ionizing radiation can also activate BK channels to induce migration.