TRPM7 and central nervous system cancer: RTK/RAS/RAF/MEK/ERK signal cascade is essential in intercellular and intracellular communication and is a ubiquitous signal transduction pathway.152 It is often altered in disease and causes many human syndromes and conditions, including cancer.153 To date, RTK/RAS/PI3K and MAPK/ERK signaling pathways related to TRPM7 are closely associated with the migration, invasion, and proliferation of glioma, which are crucial for glioma progression.