Research confirmed that TRPM2 and TRPM3 have anti-tumor effects, while TRPM7 and TRPM8 may be related to glioma malignancy (such as proliferation).25 For example, Ca2+ permeates TRPM2 channels to enhance H2O2-induced human A172 glioma cell death.26 TRPM7 suppression significantly inhibited the growth, proliferation, migration and invasion of A172 cells.27 In addition, the expression level of TRPM8 was significantly correlated with the aggressiveness of glioma cells.28 These make the TRPM channels a potential prognostic indicator and therapeutic target. Here, TRPM8 is linked to central nervous system cancer.