It suggested that TRPM7 channels may promote GBM angiogenesis.141 As mentioned above, TRPM7 is a bifunctional protein containing an ion channel and kinase structure.142 Although TRPM7 mediates cell migration, invasion, and proliferation in glioma, migration and invasion ability are mainly increased by α-kinase domains, while proliferative capacity is increased by ion channel activity.24,61 These lines of evidence suggest that TRPM7 channels and kinase domains are closely related to glioma proliferation, migration, and invasion. The gene discussed is TRPM7; the disease is glioma.