Pharmacological inhibition of the channels was confirmed to eliminate cell migration and menthol-stimulated intracellular Ca2+ influx.179 Furthermore, ionizing radiation, which induces migration through Ca2+ -mediated activation of BK channels, has been shown to activate and upregulate TRPM8-mediated Ca2+ influx in glioma cells,144 thus confirming the direct interplay of the two channels in controlling glioma migration. This evidence concerns the gene KCNMA1 and central nervous system cancer.