CLIC1 and central nervous system cancer: TRPM7 is widely expressed throughout the body and is closely associated with many central nervous system lesions, including glioma.121,139 For example, one study has found that TRPM7 channels are closely related to the angiogenesis of glioma.140 Another study demonstrated TRPM7-dependent CLIC1 vesicles translocated to microvascular endothelial cells in glioma.