EGF and central nervous system cancer: For example, one study found that growth factors such as EGF and VEGF regulate TRPM7 activity through the RTKS signaling pathway.154 Another study confirmed that TRPM7 enhances the MAPK/ERK and/or PI3K/Akt pathways in various cancers, including glioma.155,156 Furthermore, MAPK/ERK and PI3K/Akt are essential signaling pathways that show key roles in glioma migration, invasion, and proliferation.