TRPM8 and glioblastoma: Early studies found that in more than 20 TRP channels, compared with normal brain tissue, TRPM8 mRNA expression in GBM was upregulated to the highest level, which was closely related to the migration, invasion, and proliferation of glioma.143 TRPM8 suppression or knockdown has been shown to disrupt the trigger of apoptotic cell death, cell cycle, cloning survival, and impair DNA repair.144 TRPM8 channels may also regulate cell proliferation by dynamically controlling the level of glioma resting potential, which may be a crucial cell cycle regulator.