Oxidative stress is a prominent feature of many pathologies, and a common mechanism is to induce cell death by disrupting intracellular ion homeostasis.73 Recent evidence suggests that TRPM2 channels are susceptible to oxidative stress activation and play a vital part in oxidative stress-induced cell death, including gliomas.128 For example, introducing TRPM2 into human glioblastoma multiforme (GBM) cells enhanced the hydrogen peroxide-induced apoptosis. Here, TRPM2 is linked to central nervous system cancer.