The results showed that TRPM2 was involved in the mechanism by which resveratrol enhanced the effect of paclitaxel.171 Paclitaxel and resveratrol further increased apoptosis by increasing intracellular ROS levels and inducing mitochondrial dysfunction, suggesting that TRPM2 plays a role in regulating apoptosis in GBM cells. The gene discussed is TRPM2; the disease is glioblastoma.