MMP2 and glioblastoma: Moreover, Naltriben has been shown to enhance GBM migration and invasion by inducing TRPM7-like currents through Ca2 + influx, associated with increased activation of MAPK/ERK-related proteins.99 Interestingly, Naltriben also enhanced TRPM7 channel activity, possibly by upregulating the MAPK/ERK signaling pathway and MMP-2 protein expression to enhance GBM migration and invasion.