Four members of the TRPM channels, TRPM2, 3, 7, and 8, are widely involved in the signal transduction process of glioma, such as cell-death-related signaling pathways, RTK/RAS/PI3K signaling pathways, MAPK/ERK signaling pathways, JAK2/STAT3/Notch signaling pathway, miR-28-5p/Rap1b axis, CaMKII, BK, and Kir4.1-K+ channels, etc. These signaling pathways are reviewed in detail below, as shown in Figure 3(a–d). Here, TRPM2 is linked to central nervous system cancer.