AKT1 and central nervous system cancer: Like xyloketal B, carvacrol has been reported to induce xykeob-like effects in glioma by inhibiting MAPK/ERK and PI3K/AKT signaling pathways.121 In parallel experiments, it was found that carvacrol could reduce expression levels of p-Akt and p-ERK1/2, the cell viability, migration, and proliferation in GBM cells.