Its loss of expression is a marker of poor prognosis in GBM patients because TRPM3 expression is significantly down-regulated with increased glioma grade.63 Furthermore, DNA methylation of the TRPM3 promoter was positively correlated with glioma dryness and migration.137 Moreover, TRPM3 has also been closely related to glioma growth and autophagy,138 but its mechanism needs further research. The gene discussed is TRPM3; the disease is central nervous system cancer.