As previously mentioned, miR-28-5p also is a tumor suppressor whose downregulation leads to significantly increased proliferation and invasion of glioma.61 In the target of miR-28-5p, the expression of Rap1b in GBM was positively correlated with TRPM7 and negatively correlated with miR-28-5p. The gene discussed is RAP1B; the disease is central nervous system cancer.