Interestingly, Vacquinol-1 (VQ-1)-induced multitype glioblastoma cell death was in contrast to exogenous ATP-induced TRPM7 activity.176 The study of TRPM7 and its specific pharmacological inhibition confirmed that inhibition of AKT or ERK inhibitors is crucial for controlling GBM growth and invasion. The gene discussed is AKT1; the disease is glioblastoma.