IGFBP3 and metabolic dysfunction-associated steatotic liver disease: Interestingly, proteins from the Insulin growth factor (IGF) family have also been identified as potential biomarkers of fibrosis in patients with MASLD: IGF-1 (Insulin-like Growth Factor 1) [44] and IGFBP3 and 4 (Insulin-like Growth Factor Binding Protein-3 and -4) [44, 45].