We then examined the association between CNV and the expression of Ras GTPase-activating proteins in pan-cancers, and our findings confirmed that the CNV of NF1, RASA1, RASA2, RASA3, and SYNGAP1 was highly correlated with their respective expression in a wide variety of cancers, including BRCA, LUSC, OV, LUAD, SKCM, STAD, HNSC, and others(Fig. 7D). This evidence concerns the gene NF1 and cancer.