The decrease or lack of sDKK3 level may accelerate atherosclerosis and exacerbate the formation of new intima, which may also negatively affect the functional outcome after AIS [33] In addition, DKK3 is involved in the proliferation, differentiation, and survival of nerve cells and changes in cerebral blood flow, especially in the context of acute or gradual reduction of cerebral perfusion [17]. The gene discussed is DKK3; the disease is atherosclerosis.