For the LIHC dataset, among the biomarkers identified from the SNV data, it has been proved that low expression of CYP2E1 may play a crucial role in promoting the malignant progression of hepatocellular carcinoma, which could serve as a potential biomarker for predicting the prognosis of hepatocellular carcinoma [39]. Here, CYP2E1 is linked to hepatocellular carcinoma.