However, the three patients with chronic lymphocytic leukemia [mean = 141.3, 95% CI (107.0–175.7)] had significantly higher baseline age-adjusted p16 levels than those with plasma cell disorders [mean = 28.4, 95% CI (13.7–43.2) p = 0.02]. The gene discussed is CDKN2A; the disease is B-cell chronic lymphocytic leukemia.