CHMP5 and infection: We tested the hypothesis that the lack of association in our study was due to an absence of prior infection with OC43-CoV or HKU1-CoV by examining the data for the SARS-CoV-2 Human Challenge Characterisation Study (ClinicalTrials.gov identifier NCT04865237; funder, UK Vaccine Taskforce), in which 34 participants seronegative to spike protein were challenged with D614G-containing pre-Alpha SARS-CoV-2, of whom 33 consented for genetic analysis.19