Notably, while confirming that the HIF-1α inhibitor YC-1 has no significant cytotoxicity on glioma cells (Additional file 1: Fig. S5), we have noticed that YC-1 downregulates the expression of LAMC1 while inhibiting HIF-1α expression at the same time (Fig. 9C, D, Additional file 1: Fig. S4B). This evidence concerns the gene LAMC1 and central nervous system cancer.