ESRRA and obesity due to melanocortin 4 receptor deficiency: ERRα can regulate the metabolic pathways related to the tricarboxylic acid cycle and β-oxidation and mitochondrial metabolism [29–31], showing the effects of PGC-1α in the fat metabolism which is necessary in weight management. In addition, UCP-2 is a key regulator of energy expenditure in the mitochondria and they have a pivotal role in the management of obesity, hyperinsulinemia, and metabolic syndrome [32].