However, few studies assess the changes in PGC-1α and UCP-2 post-operatively, and due to the important role of mitochondrial dysfunction in obesity pathogenesis or lack of success in non-surgical weight loss programs, the aim of this study was to evaluate the changes in serum PGC-1α and UCP-2 simultaneously with the changes in weight and body composition, insulin resistance, blood lipids, insulin, and glycemic control, liver enzymes, and their relationships. This evidence concerns the gene PPARGC1A and obesity disorder.