PCOS, one of the considerable diseases that restrict reproductive outcome, has been vigorously characterized by increased inflammation, oxidative stress, mitochondrial dysfunction, detrimental modification in cell signaling pathways (such as phosphoinositide-3-kinase-protein kinase B/AKT or PI3K-AKT), hyperinsulinemia and infertility [6]. The gene discussed is AKT1; the disease is Hyperinsulinemia.