Recent studies have widely reported that the PI3K/AKT signaling pathway is dysregulated in both patients with PCOS and animal models of PCOS, additionally the critical role of the PI3K-AKT signaling pathway in regulating of the growth, development, differentiation, and survival of ovarian follicles were documented [12, 70]. The gene discussed is AKT1; the disease is polycystic ovary syndrome.