For instance, we need to investigate: (1) Y-2 efficacy in male 5×FAD mice, (2) Y-2 efficacy in other AD animal models, e.g. a Tau model, (3) Y-2 pharmacokinetic studies in AD animal models, (4) Y-2 efficacy in aged mice (with treatment started after amyloid pathology), (5) Y-2 may affect microglia-mediated inflammation and Aβ clearance. This evidence concerns the gene MAPT and Alzheimer disease.