Regarding Familial Partial Lipodystrophy (FPLD), the main subgroups, FPLD2 to 6, are associated with pathogenic variants in LMNA, PPARG, PLIN1, CIDEC and LIPE respectively, whereas FPLD1 is thought to be of polygenic origin [6, 7]. Here, NOTCH3 is linked to familial partial lipodystrophy.