Regarding Familial Partial Lipodystrophy (FPLD), the main subgroups, FPLD2 to 6, are associated with pathogenic variants in LMNA, PPARG, PLIN1, CIDEC and LIPE respectively, whereas FPLD1 is thought to be of polygenic origin [6, 7]. The gene discussed is LIPE; the disease is familial partial lipodystrophy.