Nevertheless, the positive correlation between SIRT-1 levels and lung function/severity of IPF and the increased levels of SIRT-3, along with the lack of significant differences in SIRT-6 and SIRT-7 levels between patients and controls, underscores the potential utility of SIRT-1 and SIRT-3 as potential indicators of disease progression in IPF. Here, SIRT7 is linked to idiopathic pulmonary fibrosis.