As illustrated in Fig. 2a and detailed in Table 1, we observed a significant reduction in serum SIRT-1 levels among IPF patients compared to controls (median IPF 667 [435–858] pg/mL vs. controls 925 [794–1173] pg/mL; p < 0.001). The gene discussed is SIRT1; the disease is idiopathic interstitial pneumonia.