Our study explored the relationship between condensates formation and tumorigenesis, revealed the mechanism of oncogenic fusion protein SS18-SSX mediating carcinogenesis through remodeling 3D genome structure and excluding HDACs complexes, and found that H3K27ac enriched on SS18-SSX1 condensates may be a new target for the treatment of synovial sarcoma. The gene discussed is SS18; the disease is synovial sarcoma.