However, SS18(YA)-SSX mutant fails to activate the downstream genes (Supplementary Fig. 3e) and loses tumorigenicity based on EdU cell proliferation assay (Supplementary Fig. 3f, g), colony formation assay (Supplementary Fig. 3h, i) and tumor-bearing mouse models (Supplementary Fig. 3j-l), suggesting that the tyrosine-based condensation also plays a critical role in its tumorigenic potential. Here, SS18 is linked to neoplasm.