Our study explored the relationship between condensates formation and tumorigenesis, revealed the mechanism of oncogenic fusion protein SS18-SSX mediating carcinogenesis through remodeling 3D genome structure and excluding HDACs complexes, and found that H3K27ac enriched on SS18-SSX1 condensates may be a new target for the treatment of synovial sarcoma. Here, SSX1 is linked to synovial sarcoma.