Indeed, an examination of 10,788 control couples unveiled significant disparities in baseline characteristics, such as age, basal FSH, AFC, infertility type, infertility factors, stimulation protocol, and stage of the transferred embryo, between those undergoing IVF treatment (n = 7407) and those undergoing ICSI treatment (n = 3381) (Table S4). This evidence concerns the gene BRD2 and Infertility.