PROS1 and Peutz-Jeghers syndrome: As shown in Fig. 9, 10 metabolic pathways showed lower P values and higher pathway enrichment rates between Groups P and H, including glycosylphosphatidylinositol (GPI)-anchored protein biosynthesis, asthma, pyrimidine metabolism, taste transduction, 5-hydroxytryptamergic synapse, linoleic acid, α-linolenic acid metabolism, purine metabolism, arachidonic acid metabolism, and glycerophospholipid metabolism, suggesting that these metabolic pathways may play a special role in the clinical manifestations of PJS patients.