MTNR1B and preeclampsia: Our study also identified potential lncRNA-mRNA pairs through cis-regulatory analysis, involving important mRNAs related to early-onset PE, such as FLT1, INHBA, FAM47E-STBD1, and MTNR1B. Of these mRNAs, FLT1 and INHBA are associated with cytokine-cytokine receptor pathway and are highly expressed in preeclampsia [23, 50] whereas the roles of FAM47E-STBD1 and MTNR1B in preeclampsia remain unknown.