VEGFA and medical procedure: Zhang et al.’s [38] study on seawater aspiration-induced acute lung injury showed that Sema7A induces the expression of vascular endothelial growth factor (VEGF), a well-known endothelial permeability-related protein, and promotes hyperpermeability of pulmonary microvascular endothelial cells by interacting with plexin C1, while a study from Hu et al. [34] focused on atherosclerosis showed that Sema7A promotes VEGF-mediated endothelial permeability via interaction with integrin β1, suggesting a disease-context dependent feature of Sema7A.