Importantly, PDK4 expression has been revealed to be up-regulated in breast cancer tissues (Guda et al. 2018) and PDK4 is involved in Warburg effect, drug resistance and aggressive cellular behaviors in breast cancer (Guda et al. 2018; Dwyer, et al. 2023; Huang et al. 2021; Walter et al. 2015). This evidence concerns the gene PDK4 and breast carcinoma.