In the MCa-M3C mouse model, increased CD8+ T cell and DC (Gr-1+CD11c+) numbers and decreased Treg cell numbers (CD4+FOXP3+) in tumor tissues, and increased CD8+ T cell numbers in spleens were found in IR + DSF/Cu-treated mice (Fig. 6C, D). The gene discussed is ITGAX; the disease is neoplasm.