It should also be noted that these same regions in the proximity of WNT loci are bound by E2F1 or E2F4 in other cancer types including breast cancer as shown by E2F1 and E2F4 ChIP-sequencing data analyses46–49 (Fig. 3i and Supplementary Fig. 3f, g), suggesting that some E2F binding regions are shared across diverse cancer types including BRCA and PDAC. Here, E2F4 is linked to breast cancer.