Computational analysis of published E2F1 ChIP-seq data from breast cancer cells46–48 and E2F4 ChIP-seq in lymphoblastoid cells49 revealed that multiple WNT loci such as WNT7B, WNT3A, WNT9A and other WNT loci are bound by E2F1 and/or E2F4 (Fig. 8a and Supplementary Fig. 3f, g) in the proximal promoter in the genomic region within 5 kb upstream of TSS to 3 kb downstream of the gene, indicating the WNT loci are directly regulated by E2Fs not only in breast cancer but also in lymphoblastoid cells. Here, E2F4 is linked to breast carcinoma.