Computational analysis of published E2F1 ChIP-seq data from breast cancer cells46–48 and E2F4 ChIP-seq in lymphoblastoid cells49 revealed that multiple WNT loci such as WNT7B, WNT3A, WNT9A and other WNT loci are bound by E2F1 and/or E2F4 (Fig. 8a and Supplementary Fig. 3f, g) in the proximal promoter in the genomic region within 5 kb upstream of TSS to 3 kb downstream of the gene, indicating the WNT loci are directly regulated by E2Fs not only in breast cancer but also in lymphoblastoid cells. This evidence concerns the gene WNT7B and breast carcinoma.